Impact

• Development of better therapeutic interventions for three frequent and hard-to-treat cancer types (breast cancer, colorectal cancer, pancreatic cancer)
• Strategies to overcome treatment resistance and metastasis, resulting in a gain in quality-adjusted life years for patients
• Improved understanding of ITH through longitudinal and spatially annotated (primary tumor, metastases) sampling of cancer tissue and blood from individual cases with the most advanced methodological approaches
• Generate substantial knowledge on how to target ITH and use this knowledge to design innovative clinical trials