Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response

Hofer S, Frasch L, Brajkovic S, et al. Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response (PMID: 39838187). Mol Syst Biol. 2025.

Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence

Keyl J, Keyl P, Montavon G, et al. Decoding pan-cancer treatment outcomes using multimodal real-world data and explainable artificial intelligence (PMID: 39885364). Nat Cancer. 2025.

Minimally invasive determination of pancreatic ductal adenocarcinoma (PDAC) subtype by means of circulating cell-free RNA

Metzenmacher M, Zaun G, Trajkovic-Arsic M, et al. Minimally invasive determination of pancreatic ductal adenocarcinoma (PDAC) subtype by means of circulating cell-free RNA (PMID: 39478658). Mol Oncol. 2025.

Biopsy-derived organoids in personalised early breast cancer care: Challenges of tumour purity and normal cell overgrowth cap their practical utility

Schwerd-Kleine P, Wurth R, Cheytan T, et al. Biopsy-derived organoids in personalised early breast cancer care: Challenges of tumour purity and normal cell overgrowth cap their practical utility (PMID: 40022208). Int J Cancer. 2025.

Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model

Starostecka M, Jeong H, Hasenfeld P, et al. Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model (PMID: 39993200). Proc Natl Acad Sci U S A. 2025.

KRASG 12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening

Tapia Contreras C, Falke JD, Seifert DM, et al. KRAS(G) (12C)-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening (PMID: 39253995). Mol Oncol. 2025.

Characterization of single neurons reprogrammed by pancreatic cancer

Thiel V, Renders S, Panten J, et al. Characterization of single neurons reprogrammed by pancreatic cancer (PMID: 39961335). Nature. 2025.

Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling

Wurth R, Donato E, Michel LL, et al. Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling (PMID: 39753722). Nat Cancer. 2025.

PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

Zhao B, Fang R, Schurmann H, et al. PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma (PMID: 40188436). Cell Rep. 2025.